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 National Science
Foundation Award #0541119 |
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Enhancing Productivity and Protein Quality in Perfusion Cultures |
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| Investigator(s): |
Dhinakar Kompala (PI)
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| Sponsor: |
University of Colorado at Boulder, CO 80309 3034926221
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| Start Date/Expiration Date |
2006-05-01 to 2008-04-30 (amended 2006-04-03) |
| Awarded Amount to Date: |
$178,295 |
| Abstract: 0541119
Kompala
The therapeutic efficacy of a biopharmaceutical protein is extremely sensitive to the production conditions because they influence post-translation modifications. Therefore, any new concept for production of such proteins used in humans requires thorough characterization of its impact on the integrity of the product. The proposed study will investigate the author's hypothesis that slow growing perfusion cultures produce more therapeutically relevant glycoproteins compared to those produced in faster growing batch cultures. This proposal addresses an issue that has profound consequences from the practical perspective of advancing the development of an important new class of therapeutic agents (i.e., recombinant glycoproteins). Success in this area will have a significant financial payoff. In addition, from the perspective of "advancing knowledge" this proposal also has as one of its aims the goal of better understanding the underlying biological processes that determine glycosylation patterns. |
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| NSF Org: |
BES - Division of Bioengineering & Environmental Systems |
| Award Number: |
0541119 |
| Award Instrument: |
Continuing grant |
| Program Manager: |
Lenore S. Clesceri
BES Division of Bioengineering & Environmental Systems
ENG Directorate for Engineering
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| NSF Program(s): |
BIOCHEMICAL & BIOMASS ENG |
| Field Application(s): |
Industrial Technology |
| Program Reference Code(s): |
BIOPROCESSING/BIOMOLECULAR MATERIALS, 9181
PROTEIN AND ENZYME ENGINEERING, 017E |
| Program Element Code(s): |
1402 |
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