|
|
|
 |
 National Science
Foundation Award #0541766 |
 |
|
|
Purchase of a Cyber-Enabled Diffractometer |
| |
| Investigator(s): |
Lawrence Sayre (PI)
; John Protasiewicz (Co-PI)
|
| Sponsor: |
Case Western Reserve University, OH 44106 2163684510
|
| Start Date/Expiration Date |
2006-02-15 to 2009-01-31 (amended 2006-02-02) |
| Awarded Amount to Date: |
$331,901 |
| Abstract: With support from the Chemistry Research Instrumentation and Facilities-Departmental Multiuser Instrument Acquisition (CRIF-MU) Program, the Department of Chemistry at Case Western Reserve University will acquire a single-crystal X-ray diffractometer with CCD detector and low temperature capability. Research projects that will be enhanced by this instrument includes studies on (a) the mechanism of amine oxidation catalyzed by the copper/quinine-dependent amine oxidases and the design of mechanism-based inactivators; b) modification of proteins by lipid and sugar oxidation products during oxidative stress; c) novel oligomeric and polymeric materials; d) characterization of nanosized aggregates that form at the outset of biomineralization; d) highly controlled asymmetric reactions; e) synthesis of new and unusual three-dimensional architectures; and f) properties of metal macrocycles.
The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. These studies will have an impact in a number of areas, especially synthetic chemistry, materials science and biochemistry. In addition, the diffractometer will be cyber-enabled to allow access to users at remote locations. |
|
| NSF Org: |
CHE - Division of Chemistry |
| Award Number: |
0541766 |
| Award Instrument: |
Standard Grant |
| Program Manager: |
Robert L. Kuczkowski
CHE Division of Chemistry
MPS Directorate for Mathematical & Physical Sciences
|
| NSF Program(s): |
CHEMICAL INSTRUMENTATION |
| Field Application(s): |
|
| Program Reference Code(s): |
CYBERINFRASTRUCTURE/SCIENCE, 7569
SINGLE DIVISION/UNIVERSITY, 9161 |
| Program Element Code(s): |
1938 |
|
|
| |
 |
|
|
|
|
|
|
|
